Osteoarthritis (OA) is the second most common age-related
problem that affects quality of life24 and it is the most frequent
joint disease in India, with a prevalence of 22% to 39%2. OA is more
common in women than men, but the prevalence increases dramatically with age24,25,26. Nearly
45% of women over the age of 65 years have symptoms while radiological evidence
is found in 70% of them25,26,27. 

OA was estimated to be the 10th leading cause
of nonfatal burden25,27.OA of the knee is a major cause of mobility
impairment, particularly among females25,26,28,29. Osteoarthritis
accounts for decrease in activities of daily living (ADL) in elderly dependent
population in the community5.

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Although osteoarthritis affects both males and females,
prevalence of osteoarthritis reported to increase in females during
peri-menopausal age and remains high throughout menopause as compared to males. Numerous experimental, clinical and epidemiological studies
suggest that loss of estrogen at the time of menopause increase a woman’s risk of
getting osteoarthritis30. Average menopausal age in Indian
women is 46.3 years as compared to 51 years in western countries. 31 This
predisposes Indian women to the risk of developing osteoarthritis at earlier
age compared to their western counterparts.

Salve et al
conducted a study in south Delhi in 2010 regarding the prevalence of knee
osteoarthritis in south Delhi and found that 47.8% women of age  >40years 
are suffering from knee osteoarthritis32. Elizabeth et al conducted a similar study in urban Bangalore,
and found that the mean age of the population was 42.56 ±16.5 years. The
corresponding prevalence of osteoarthritis calculated using the ACR and the
EULAR 2009 criteria were 17% and 5.6% in the adult population and 54.1% and
16.4% in the elderly>60 years.
Etiological factors found associated with osteoarthritis were age
(p